Tissue Lysates
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Cayman Chemical SynthetIc BufotalIn 1mg
A bufadienolide with cytotoxic and immunomodulatory activities; induces cell cycle arrest at the G1 phase and apoptosis in Hep3B cells from 0.13-1.13 µM; reduces autoantibody production, serum levels of TNF-α, IL-1β, IFN-γ, IL-22, and IL-17, and the number of splenic and lymph node Th17 cells, as well as increases saliva flow rates in a mouse model of experimental Sjörgren’s syndrome at 100 UG/kg; induces lethality in anesthetized dogs (LD50 = 0.36 mg/kg)
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Cayman Chemical SynthetIc AlysIn 1mg
An isothiocyanate with diverse biological activities; active against a variety of bacteria; directly inhibits PAH-induced CYP1A1 and CYP1A2 activity in MCF-7 cells at 0.5-2.5 µM; inhibits proliferation of HCT116 colon cancer cells (IC50 = 50s = 168 and 20 µM, respectively)